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Atypical Depression: A Distinct Clinical Subtype?
This month’s article comes to us from one of our premier journals, Biological Psychiatry, which focuses on the underlying mechanisms in mental illness. The authors sought to determine if atypical depression is a distinct clinical subtype based on clinical characteristics, genetic profile, and antidepressant response.
Although this question has been debated for 60 years, this new article promises a comprehensive study using the latest technology. Does the presence of atypical symptoms of depression such as weight gain and hypersomnia signal which treatments would be most effective?
Study Design and Population
The subjects were drawn from the Australian Genetics of Depression Study, composed predominantly of subjects with severe recurrent depression. The current study included the subjects that provided a saliva sample for genetic testing, which was 76% of the total cohort or 14,897 subjects.
Polygenic scores were created for the 95% of subjects with European
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