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Do you prescribe antidepressants for people living with bipolar? Whether you say yes or if you are one of the few who say no, we all are frequently faced with important antidepressant questions.
- How risky are antidepressants in people with bipolar?
- How well do they work?
- Could they only be used short term? A new review by Lars Kessing, a highly respected Danish mood specialist, provides a sober, balanced comparison of research evidence and clinical practice regarding antidepressants for people with a bipolar diagnosis.
Antidepressants Efficacy in Bipolar Depression
First, do antidepressants even work in bipolar depression? Kessing confirms antidepressants are better than placebos. Interestingly, the effect size in bipolar depression ranging in studies from 0.2 to 0.4 in different meta-analyses is very close to the effect size in unipolar depression, about 0.3 (you’ll recall that an effect size of 1.0 is large; 0.5 is medium; 0.3 is a small
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